Hyperinfection syndrome should be considered a potential medical emergency. Thus, treatment should be started immediately if this is being considered. Strongyloides stercoralis Hyperinfection remain quiescent indefinitely, immunosuppression can lead to the hyperinfection syndrome, which is. Whereas in chronic strongyloidiasis and in hyperinfection syndrome the larvae are limited to the GI tract and the lungs, in disseminated.

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Strongyloides stercoralis eosinophilic granulomatous enterocolitis. Published online May National Center for Biotechnology InformationU. Unsuspected strongyloidiasis in hospitalised elderly patients with and without eosinophilia. These goblet cells were induced by IL secreted by Th 2 cells [ 81 ]. Don’t already have an Oxford Academic account? Neonatal vitamin A supplementation and hyperinfectioon responses to oral polio vaccine in Zimbabwean infants.

A Fatal Strongyloides Stercoralis Hyperinfection Syndrome in a Patient With Chronic kidney Disease

Byperinfection on strongyloidiasis in the immunocompromised host. Subcutaneous ivermectin use in the treatment of severe Strongyloides stercoralis infection: Eur J Intern Med. This means that the parasite never reaches the soil; instead, it re-enters the host via enteral circulation endoautoinfection or perianal skin exoautoinfection. Global prevalence of strongyloidiasis: Infect Immun ; The patient is a farmer who was originated from a rural area in Zhejiang Province, China.

Intestinal strongyloidiasis and hyperinfection syndrome

Fluctuations of larval excretion in Strongyloides stercoralis infection. The surveillance could be done in the form of repeat eosinophil counts along with serological surveillance with serial antibody titers and multiple stool specimens for larvae. Strongyloidiasis, synsrome the hyperinfection syndrome and more systemic disseminated infection, can sometimes mimic pneumonia [ 58 ], polyarteritis nodosa [ 59 ], malignant mediastinal neoplasia [ 60 ], eosinophilic folliculitis [ 61 ], relapse of lymphoma [ 62 ], primary intestinal lymphoma [ 38 ], flare up of systemic lupus erythematosus [ 63 ], peptic ulcer disease [ hyperinfecction ], and ulcerative colitis or crohn’s hyperinfecrion [ 4064 ].


Molecular diagnostics of intestinal parasites in returning travellers. Further studies mainly involving voluntary human subjects are required to confirm this possibility.

CDC – Strongyloides – Resources for Health Professionals

Mast cells are also shown to play an important role in the defense against parasite infestations [ 82 ] and are considered as the hylerinfection cells against Strongyloides species even in humans [ 90 ]. Vaccines, which are effective against infective stage filariform larvae could be a possibility based on the experimental evidence in mice, especially if composed of multiple antigens [ 9899, ].

This idea is exemplified by the patient described earlier. On day 4 of admission, laboratory results revealed that white blood cell count was reduced to 1. The initial direct fecal smear stool examination in the referring hospital was negative, while multiple specimens were positive in our hospital.

The safety of albendazole in children less than 6 years old is not certain. Sub-acute intestinal obstruction by Strongyloides stercolaris.


Resources for Health Professionals. Relapses, especially involving gastrointestinal tract, were noted even after treatment of strongyloidiasis. He was labeled as reactive psychosis and started on citalopram. Table of Contents Alerts.

J Assoc Physicians India ; In a study reported by Trajman et al. I agree to the terms and conditions. Hyperinfection syndrome is estimated to happen in 1. Eosinophilia is not a cost effective strategy compared to the stool examinations with agar plate culture method and serological testing in detecting strongyloides infection in humans hyperifection 67 ].

We considered there were 2 main reasons of the treatment failure in this case. To avoid fatal outcomes because of strongyloidiasis, routine investigation and hyperinfwction treatment of strongyloidiasis in patients with chronic kidney disease who will undergo immunosuppressive therapy is necessary. Pulmonary strongyloidiasis in hyprinfection patient receiving prednisolone therapy—.

Through literature review, we recommend that strongyloidiasis should be routinely investigated in patients with chronic kidney disease who will undergo immunosuppressive therapy.

Strongyloidiasis among patients with chronic kidney disease is rarely reported.